Publications

Our Innovation

2024

Ischemia-induced endogenous Nrf2/HO-1 axis activation modulates microglial polarization and restrains ischemic brain injury

Kuo PC, Weng WT, Scofield BA, Paraiso HC, Yu IC I, Yen JH J

Frontiers in Immunology. 2024. 15:1440592. doi: 10.3389/fimmu.2024.1440592

2023

Editorial: [Ischemic Stroke as Systemic Disorder Involving both Nervous and Immune Systems]

Liu Q, Wang Y, Yen JH J

Frontiers in Cellular Neuroscience. 2023. 17. doi: 10.3389/fncel.2023.1208787

Interferon-β modulates microglial polarization to ameliorate delayed tPA-exacerbated brain injury in ischemic stroke

Kuo PC, Weng WT, Scofield BA, Paraiso HC, Bojrab P, Kimes B, Yu IC I, Yen JH J

Frontiers in Immunology. 2023. 14:1148069. doi: 10.3389/fimmu.2023.1148069

Evaluation of benzoylacetonitriles as novel anti-neuroinflammatory agents

Clauser K, Salae, J, Leavell B, John-Pikel KS, Kuo PC, Yen JH, Brown DA

Med Chem Res. 32, 802–807 (2023). https://doi.org/10.1007/s00044-023-03049-3

The role of ApoE-mediated microglial lipid metabolism in brain aging and disease

Yen JH J, Yu IC I.

Immunometabolism. 2023. 5(1):p e00018. DOI: 10.1097/IN9.0000000000000018

Targeting Nrf2 with 3H-1,2-dithiole-3-thione to moderate OXPHOS-driven oxidative stress attenuates IL-17A-induced psoriasis

Liu CT, Yen JH J, Brown DA, Song YC, Chu MY, Hung YH, Tang YH, Wu PY, Yen HR.

Biomedicine & Pharmacotherapy. 159 (2023) 114294.

2022

4-Ethylguaiacol modulates neuroinflammation and promotes heme oxygenase-1 expression to ameliorate brain injury in ischemic stroke

Weng WT, Kuo PC, Scofield BA, Paraiso HC, Brown DA, Yu IC, Yen JH.

Frontiers in Immunology. 2022. 13:887000.

Adipose-derived stromal cells reverse insulin resistance through inhibition of M1 expression in a type 2 diabetes mellitus mouse model

Chen LW, Chen PH, Tang CH, Yen JH

Stem Cell Research & Therapy. 2022 Jul 26;13(1):357.

2021

Immunoresponsive gene 1 modulates the severity of brain injury in cerebral ischemia

Kuo PC, Weng, WT, Scofield BA, Furnas D, Paraiso HC, Yu IC, Yen JH.

Brain Communications. 2021 Aug 19;3(3):fcab187.

Inhibiting adipose tissue M1 cytokine expression decreases DPP4 activity and insulin resistance in a type 2 diabetes mellitus mouse model

Chen LW, Chen PH, Yen JH.

PLoS One. 2021 May 27;16(5):e0252153.

4-Ethylguaiacol modulates neuroinflammation and Th1/Th17 differentiation to ameliorate disease severity in experimental autoimmune encephalomyelitis

Weng WT, Kuo PC, Brown DA, Scofield BA, Furnas D, Paraiso HC, Wang PY, Yu IC, Yen JH.

J Neuroinflammation. 2021 May 11;18(1):110.

2020

Interferon beta alleviates delayed tPA-induced adverse effects via modulation of MMP3/9 production in ischemic stroke

Kuo PC, Weng WT, Scofield BA, Furnas D, Paraiso HC, Intriago AJ, Bosi KD, Yu IC, Yen JH.

Blood Advances. 2020 Sep 22;4(18):4366-4381.

Dimethyl itaconate, an itaconate derivative, exhibits immunomodulatory effects on neuroinflammation in experimental autoimmune encephalomyelitis.

Kuo PC, Weng WT, Scofield BA, Paraiso HC, Brown DA, Wang PY, Yu IC, Yen JH.

J Neuroinflammation. 2020 Apr 29;17(1):138.

Isolation of Mouse Cerebral Microvasculature for Molecular and Single-Cell Analysis.

Paraiso HC, Wang X, Kuo PC, Furnas D, Scofield BA, Chang FL, Yen JH, Yu IC.

Front Cell Neurosci. 2020 Apr 9;14:84.

2019

Serotonin receptor HTR6-mediated mTORC1 signaling regulates dietary restriction-induced memory enhancement.

Teng LL, Lu GL, Chiou LC, Lin WS, Cheng YY, Hsueh TE, Huang YC, Hwang NH, Yeh JW, Liao RM, Fan SZ, Yen JH, Fu TF, Tsai TF, Wu MS, Wang PY.

PLoS Biol. 2019 Mar 18;17(3):e2007097.

2018

Dithiolethione ACDT Suppresses Neuroinflammation and Ameliorates Disease Severity in Experimental Autoimmune Encephalomyelitis.

Kuo PC, Brown DA, Scofield BA, Paraiso HC, Wang PY, Yu IC, Yen JH.

Brain, Behavior, and Immunity. 2018. 70:76-87.

Dimethyl fumarate protects CNS against to reactive microglia and long-term memory deficits in response to systemic inflammation.

Paraiso HC, Kuo PC, Curfman ET, Moon HJ, Sweazey RD, Yen JH, Chang FL, Yu IC.

Journal of Neuroinflammation. 2018. 29;15(1):100.

Insulin-like signaling in female Drosophila links diet and sexual attractiveness.

Lin WS, Yeh SR, Fan SZ, Chen LY, Yen JH, Fu TF, Wu MS, Wang PY.

The FASEB Journal. 2018. 32(7):3870-3877.

Identification of N-benzyl tetrahydroisoquinolines as novel anti-neuroinflammatory agents.

Gabet B., Kuo P-C., Fuentes S.l, Patel Y., Adow A., Alsakka M., Avila P., Beam T., Yen J-H., Brown D. A. Brown

Bioorganic & Medicinal Chemistry. 2018 Nov 15;26(21):5711-5717

2017

3H-1, 2-dithiole-3-thione as a novel therapeutic agent for the treatment of ischemic stroke through Nrf2 defense pathway.

Kuo PC, Yu IC, Scofield BA, Brown DA, Curfman ET, Paraiso HC, Chang FL, Yen JH.

Brain, Behavior, and Immunity. 2017. 62:180-192.

Immunomodulatory effect of G-CSF on the CNS infiltrating monocytes in ischemic stroke.

Yen JH.

Brain, Behavior, and Immunity. 2017. 60:13-14.

A combination of three repurposed drugs administered at the time of reperfusion as a promising therapy for post-ischemic brain injury.

Yu IC, Kuo PC, Yen JH, Paraiso HC, Curfman ET, Hong-Goka BC, Sweazey RD, Chang FL.

Translational Stroke Research. 2017. Dec;8(6):560-577.

Prostaglandin E2 Inhibition of IL-27 Production in Murine Dendritic Cells: A Novel Mechanism That Involves IRF1.

Hooper KM, Yen JH, Kong W, Rahbari KM, Kuo PC, Gamero AM, Ganea D.

Journal of Immunology. 2017. 198:1521-1530.

Ludwigia octovalvis extract improves glycemic control and memory performance in diabetic mice.

Lin WS, Lo JH, Yang JH, Wang HW, Fan SZ, Yen JH, Wang PY.

Journal of Ethnopharmacology. 207(2017) 211-219.

2016

3H-1, 2-dithiole-3-thione as a novel therapeutic agent for the treatment of experimental autoimmune encephalomyelitis.

Kuo PC, Brown DA, Scofield BA, Yu IC, Chang FL, Wang PY, Yen JH.

Brain, Behavior, and Immunity. 2016. 57:173-186.

Interferon beta modulates inflammatory response in cerebral ischemia.

Kuo PC, Scofield BA, Yu IC, Chang FL, Ganea D, Yen JH.

Journal of American Heart Association. 2016;5:e002610 doi: 10.1161/JAHA.115.002610.

Further structure-activity relationships study of substituted dithiolethiones as glutathione inducing neuroprotective agents.

Brown DA, Betharia S, Yen JH, Kuo PC, Mistry H.

Chemistry Central Journal. (2016) 10:64.

2015

Differential effects of IFNβ on IL-12, IL-23, and IL-10 expression in TLR-stimulated dendritic cells.

Yen JH, Kong W, Hooper KM, Emig F, Rahbari KM, Kuo PC, Scofield BA, Ganea D.

Journal of Leukocyte Biology. 2015. 98: 689-702.

Tequila regulates insulin-like signaling and extends life span in Drosophila melanogaster.

Huang CW, Wang HD, Bai H, Wu MS, Yen JH, Tatar M, Fu TF, Wang PY.

The Journals of Gerontology: Series A. 2015. 70(12):1461-9.

Reduced gut acidity induces an obese-like phenotype in Drosophila melanogaster and in mice.

Lin WS, Huang CW, Song YS, Yen JH, Kuo PC, Yeh SR, Lin HY, Fu TF, Wu MS, Wang HD, Wang PY.

PLOS ONE. 2015 Oct 5;10(10): e0139722.

2014

Synthesis and structure-activity relationships study of dithiolethiones as inducers of glutathione in the SH-SY5Y neuroblastoma cell line.

Brown DA, Betharia S, Yen JH, Tran Q, Mistry H, Smith K.

Bioorganic & Medicinal Chemistry Letters. 24(2014):5829-5831.

2013

Higher susceptibility to experiment autoimmune encephalomyelitis in Muc1-difficient mice is associated with increased Th1/Th17 responses.

Yen JH, Xu S, Park YS, Ganea D, Kim KC.

Brain, Behavior, and Immunity. 2013. 29(2013):70-81.

2012

Microbial amyloids induce IL-17A/IL-22 responses via Toll-like receptor 2 activation in the intestinal mucosa.

Nishimori JH, Newman TN, Oppong GO, Rapsinski GJ, Yen JH, Biesecker SG, Wilson RP, Butler BP, Winter MG, Tsolis RM, Ganea D, Tükel Ç.

Infection and Immunity. 2012. 80(12):4398-408.

Prostaglandin E2-induced IL-23p19 is regulated bycAMP-responsive element-binding protein and C/AATT enhancer-binding protein β in bone marrow-derived dendritic cells.

Kocieda VP, Adhikary S, Emig F, Yen JH, Toscano MG, Ganea D.

Journal of Biological Chemistry. 2012. 287(44):36922-35.

Signaling through cannabinoid receptor 2 suppresses dendritic cell migration by inhibiting matrix metalloproteinase-9 expression.

Adhikary S, Kocieda VP, Yen JH, Tuma RF, Ganea D.

Blood. 2012. 120(18):3741-9.

2011

PGE2 induces matrix metalloproteinase-9 expression in murine dendritic cells through two independent signaling pathways leading to AP-1 activation.

Yen JH, Kocieda VP, Jing H, Ganea D.

Journal of Biological Chemistry. 2011. 286(45):38913-38923.

Modulation of dendritic cell function by PGE2 and DHA: A framework for understanding the role of dendritic cells in neuroinflammation.

Ganea D, Kocieda V, Kong W, Yen JH.

Clinical Lipidology. 2011. 6(3): 277-291

Docosahexaenoic acid prevents dendritic cell maturation, inhibits antigen-specific Th1/Th17 differentiation and suppresses experimental autoimmune encephalomyelitis.

Kong W, Yen JH, Ganea D.

Brain, Behavior, and Immunity. 2011. 25(2011):872-882.

2010

IFN-β inhibits dendritic cell migration through STAT-1 mediated transcriptional suppression of CCR7 and metalloproteinase-9.

Yen JH, Kong W, Ganea D.

Journal of Immunology. 2010. 184:3478-3486.

Docosahexaenoic acid prevents dendritic cell maturation and in vitro and in vivo expression of the IL-12 cytokine family.

Kong W, Yen JH, Vassiliou E, Adhikary S, Toscano MG, Ganea D.

Lipids Health Disease. 2010 Feb 1; 9: 12.

2009

Interferon beta induces mature dendritic cell apoptosis through caspase-11 / caspase-3 pathway.

Yen JH, Ganea D.

Blood. 2009. 114(7): 1344-1354.

2008

PGE2-induced metalloproteinase-9 is essential for dendritic cell migration.

Yen JH, Khayrullina T, Ganea D.

Blood. 2008. 111(1): 260-270.

In vitro differentiation of dendritic cells in the presence of prostaglandin E2 alters the IL-12/IL-23 balance and promotes differentiation of Th17 cells.

Khayrullina T, Yen JH, Jing H, Ganea D.

Journal of Immunology. 2008. 181: 721-735.

2007

The proinflammatory effect of prostaglandin E2 in experimental inflammatory bowel disease is mediated through IL-23 / IL-17 axis.

Sheibanie AF, Yen JH, Khayrullina T, Emig F, Zhang M, Tuma R, Ganea D.

Journal of Immunology. 2007. 178:8138-8147.

A Novel VIP Signaling Pathway in T cells: cAMP / Protein Tyrosine Phosphatase (SHP-2?) / JAK2 / STAT4 / Th1 differentiation.

Liu L, Yen JH, Ganea D.

Peptides. 2007. 28(9): 1814-1824.

2004

A novel-signaling pathway mediates the inhibition of CCL3/4 expression by prostaglandin E2.

Jing H, Yen JH, Ganea D.

Journal of Biological Chemistry. 2004. 279(53): 55176-55186.

Cell type-specific interleukin-1 beta signaling in the CNS.

Srinivasan D, Yen JH, Joseph DJ, Friedman W.

Journal of Neuroscience. 2004. 24(29): 6482-6488.